{"id":3447,"date":"2020-04-28T20:18:12","date_gmt":"2020-04-28T20:18:12","guid":{"rendered":"https:\/\/news.alfaisal.edu\/?p=3447"},"modified":"2020-04-28T20:18:12","modified_gmt":"2020-04-28T20:18:12","slug":"alfaisal-university-the-featured-article-productive-new-research-about-conception","status":"publish","type":"post","link":"https:\/\/news.alfaisal.edu\/en\/alfaisal-university-the-featured-article-productive-new-research-about-conception\/","title":{"rendered":"Alfaisal University THE Featured Article: Productive New Research about Conception"},"content":{"rendered":"

This article originally appeared on the Times Higher Education and Alfaisal University research hub<\/em>: https:\/\/www.timeshighereducation.com\/hub\/alfaisal-university\/p\/productive-new-research-about-conception<\/a><\/p>\n

Alfaisal University is offering new insights into the successes and failure of fertility treatments. Modern medicine is accredited with seemingly countless discoveries and state-of-the-art, life-saving treatments. But even now, the fundamental practice of human conception is one that manages to leave scientists puzzled.<\/p>\n

However, pioneering research is under way at Alfaisal University in Saudi Arabia to improve medical understanding of infertility \u2013 a complex umbrella of issues affecting as many as one in seven couples attempting to have a child.<\/p>\n

It is a subject that Junaid Kashir, assistant professor of clinical embryology at the university\u2019s medical school, feels passionately about. One of his particular areas of research relates to a process called \u201coocyte activation\u201d, whereby calcium is released during fertilisation.\u00a0 \u201cThe best analogy that I can use to explain it is imagine you are starting a car \u2013 the sperm is the key and the egg is the car,\u201d he explains. \u201cThe process that I study is often quite literally referred to \u2018the spark of life\u2019, as it kickstarts everything.\u201d<\/p>\n

It is through this work that Dr Kashir came to be offered a five-year fellowship at Cardiff University in the UK. His project on \u201cdeveloping novel fertility treatments and diagnostics\u201d, externally funded by Health Care Research Wales, was worth $500,000 (\u00a3386,000) over five years, with additional funding provided by Saudi Arabia\u2019s National Science, Technology and Innovation Plan to the sum of 2 million Saudi riyal (\u00a3400,000) over three years.<\/p>\n

Dr Kashir seeks to investigate fertility outcomes during in vitro procedures, and his research was among the first to establish the impact of mutations and defects in a particular protein on forms of male infertility.<\/p>\n

Human sperm contains more than 1,760 proteins, each of which is thought to have a potential impact on male fertility. One of the sperm proteins that Dr Kashir studies, PLCzeta, \u201ccauses a big release of calcium\u201d, he explains. \u201cWhat\u2019s amazing about it is it\u2019s not just any random pattern \u2013 it’s more like a code that determines not only the relative success but also the quality of embryo development, and every single animal that we\u2019ve studied has its own unique code.\u201d<\/p>\n

Educated in the UK, Dr Kashir became interested in embryonic and fertility research while studying for his PhD at the University of Oxford. Now, much of what he does is driven by a desire to improve the success rate of expensive in vitro fertilisation (IVF) procedures and contribute to a more ethical industry overall.<\/p>\n

\u201cIt\u2019s a very evocative subject and even though it garners a lot of public interest, it\u2019s also one of those areas that is difficult to fund,\u201d he says. \u201cIt\u2019s not a priority in many countries \u2013 which is really bizarre, especially if you consider that a lot of what we do as a species is for the sake of reproduction and passing on our genes.\u201d<\/p>\n

Part of the reason why Dr Kashir\u2019s work on sperm proteins has gained so much interest \u2013 including from big funders \u2013 is because of its fresh approach to the potential success of IVF treatments. \u201cIVF is not very successful, if you look at the numbers,\u201d he explains. Since the mid-1980s, the practice has become widely applied across the world, with about 8 million babies born in 2018 as a direct result of IVF and associated technology.<\/p>\n

\u201cBut what these numbers don\u2019t tell you,\u201d says Dr Kashir, \u201cis that in the best-case scenario, one round of IVF in terms of successful pregnancies only has between a 25 and 30 per cent chance of success. So there\u2019s a lot of room for improvement.\u201d<\/p>\n

Babies are big business: according to the research firm Data Bridge, the fertility industry was estimated to be worth $25 billion (\u00a319.5 billion) in 2019, rising to a forecasted $41 billion (\u00a332 billion) by 2026. But Dr Kashir feels a personal responsibility to improve the success rates of IVF treatments for public health programmes in particular. \u201cYou have a lot of private clinics who offer these really expensive methods and techniques that really offer no benefit or help to the couples,\u201d he says. \u201cAnd because couples are so desperate they will try anything, and pay huge sums of money as well.\u201d<\/p>\n

Some of the studies that researchers at Alfaisal have conducted suggest correlations between levels of sperm PLCzeta and the rate of pregnancy success following fertility treatment, which could be revolutionary in terms of how scientists approach IVF going forward. \u201cEssentially what we\u2019re finding is that calcium release at fertilisation determines a heck of a lot more than just fertilisation success,\u201d he explains. \u201cImagine an intricate stack of dominoes \u2013 if the initial tip is too much or too little, something\u2019s going to go wrong further down the line. But now we know this, we can really progress in making assisted reproduction technologies more effective.\u201d<\/p>\n

A key factor in Dr Kashir\u2019s decision to base his research at Alfaisal is the level of academic freedom that he and his fellow researchers are granted, he says. For example, he was part of a team in charge of establishing a master\u2019s programme in clinical embryology and reproductive biology \u2013 the first and only programme of its kind in the Gulf region. The course is run in conjunction with the university\u2019s neighbouring King Faisal Specialist Hospital and Research Centre, where Dr Kashir is also an adjunct scientist.<\/p>\n

There is still much work to be done in order to improve the quality of IVF treatment \u2013 and this requires busting some myths surrounding gender and success rates, says Dr Kashir. \u201cIn much of the world, it is still regarded that the majority of fertility problems are down to female factors, whereas that is absolutely untrue,\u201d he explains. \u201cIt\u2019s down to educators to make the case for funding this subject. But improving the effectiveness of fertility treatment is also in part down to addressing false myths.\u201d<\/p>\n

In his view, Saudi Arabia\u2019s shift towards a knowledge-based economy provides unprecedented opportunities for researchers who want to explore pioneering research practices. \u201cAlfaisal is at the cusp of potentially huge change. The only way to go is to keep expanding our excellent research portfolio,\u201d he says.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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